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Recalibration of mapping quality scores in Illumina short-read alignments improves SNP detection results in low-coverage sequencing data
BACKGROUND: Low-coverage sequencing is a cost-effective way to obtain reads spanning an entire genome. However, read depth at each locus is low, making sequencing error difficult to separate from actual variation. Prior to variant calling, sequencer reads are aligned to a reference genome, with alig...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
PeerJ Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727374/ https://www.ncbi.nlm.nih.gov/pubmed/33354434 http://dx.doi.org/10.7717/peerj.10501 |