Farnesoid X Receptor-Mediated Cytoplasmic Translocation of CRTC2 Disrupts CREB-BDNF Signaling in Hippocampal CA1 and Leads to the Development of Depression-Like Behaviors in Mice

BACKGROUND: We recently identified neuronal expression of farnesoid X receptor (FXR), a bile acid receptor known to impair autophagy by inhibiting cyclic adenosine monophosphate response element-binding protein (CREB), a protein whose underfunctioning is linked to neuroplasticity and depression. In...

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Detalles Bibliográficos
Autores principales: Hu, Wenfeng, Wu, Jingjing, Ye, Ting, Chen, Zhuo, Tao, Jinhua, Tong, Lijuan, Ma, Kai, Wen, Jie, Wang, Hui, Huang, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Regular Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727490/
https://www.ncbi.nlm.nih.gov/pubmed/32453814
http://dx.doi.org/10.1093/ijnp/pyaa039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727490/
https://www.ncbi.nlm.nih.gov/pubmed/32453814
http://dx.doi.org/10.1093/ijnp/pyaa039

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