Cargando…

Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains

Amyloid precursor protein (APP) at the plasma membrane is internalized via endocytosis and delivered to endo/lysosomes, where neurotoxic amyloid-β (Aβ) is produced via β-, γ-secretases. Hence, endocytosis plays a key role in the processing of APP and subsequent Aβ generation. β-, γ-secretases as wel...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Yoon Young, Kwon, Oh-Hoon, Chung, Sungkwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727664/
https://www.ncbi.nlm.nih.gov/pubmed/33255194
http://dx.doi.org/10.3390/molecules25235490