Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells

RNAi technology has significant potential as a future therapeutic and could theoretically be used to knock down disease-specific RNAs. However, due to frequent off-target effects, low efficiency, and limited accessibility of nuclear transcripts, the clinical application of the technology remains cha...

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Detalles Bibliográficos
Autores principales: , Saifullah, Sakari, Matomo, Suzuki, Takeshi, Yano, Seiji, Tsukahara, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727695/
https://www.ncbi.nlm.nih.gov/pubmed/33255340
http://dx.doi.org/10.3390/ijms21238904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727695/
https://www.ncbi.nlm.nih.gov/pubmed/33255340
http://dx.doi.org/10.3390/ijms21238904

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