Absence of Mal/TIRAP Results in Abrogated Imidazoquinolinones-Dependent Activation of IRF7 and Suppressed IFNβ and IFN-I Activated Gene Production

Activation of TLR7 by small imidazoquinoline molecules such as R848 or R837 initiates signaling cascades leading to the activation of transcription factors, such as AP-1, NF-κB, and interferon regulatory factors (IRFs) and afterward to the induction of cytokines and anti-viral Type I IFNs. In genera...

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Detalles Bibliográficos
Autores principales: Leszczyńska, Ewa, Makuch, Edyta, Mitkiewicz, Małgorzata, Jasyk, Izabella, Narita, Miwako, Górska, Sabina, Lipiński, Tomasz, Siednienko, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727842/
https://www.ncbi.nlm.nih.gov/pubmed/33255528
http://dx.doi.org/10.3390/ijms21238925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727842/
https://www.ncbi.nlm.nih.gov/pubmed/33255528
http://dx.doi.org/10.3390/ijms21238925

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