Synthesis and Conformational Analysis of Fluorinated Uridine Analogues Provide Insight into a Neighbouring-Group Participation Mechanism

Fluorinated nucleoside analogues have attracted much attention as anticancer and antiviral agents and as probes for enzymatic function. However, the lack of direct synthetic methods, especially for 2′,3′-dideoxy-2′,3′-difluoro nucleosides, hamper their practical utility. In order to design more effi...

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Detalles Bibliográficos
Autores principales: Michailidou, Freideriki, Lebl, Tomas, Slawin, Alexandra M. Z., Sharma, Sunil Vishnuprasadji, Brown, Murray J. B., Goss, Rebecca Jane Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728060/
https://www.ncbi.nlm.nih.gov/pubmed/33255573
http://dx.doi.org/10.3390/molecules25235513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728060/
https://www.ncbi.nlm.nih.gov/pubmed/33255573
http://dx.doi.org/10.3390/molecules25235513

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