Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest

Systemic oxygen restriction (SOR) is prevalent in numerous clinical conditions, including chronic obstructive pulmonary disease (COPD), and is associated with increased susceptibility to viral infections. However, the influence of SOR on T cell immunity remains uncharacterized. Here we show the detr...

Descripción completa

Detalles Bibliográficos
Autores principales: Saragovi, Amijai, Abramovich, Ifat, Omar, Ibrahim, Arbib, Eliran, Toker, Ori, Gottlieb, Eyal, Berger, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728436/
https://www.ncbi.nlm.nih.gov/pubmed/33226340
http://dx.doi.org/10.7554/eLife.56612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728436/
https://www.ncbi.nlm.nih.gov/pubmed/33226340
http://dx.doi.org/10.7554/eLife.56612

Ejemplares similares