The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus

Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia, where they are thought to form a heteromeric ion channel complex. However, a functional understanding of the putati...

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Detalles Bibliográficos
Autores principales: Ha, Kotdaji, Nobuhara, Mai, Wang, Qinzhe, Walker, Rebecca V, Qian, Feng, Schartner, Christoph, Cao, Erhu, Delling, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728438/
https://www.ncbi.nlm.nih.gov/pubmed/33164752
http://dx.doi.org/10.7554/eLife.60684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728438/
https://www.ncbi.nlm.nih.gov/pubmed/33164752
http://dx.doi.org/10.7554/eLife.60684

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