REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3, in the hippocampus. BMAL1 regulates expression...

Descripción completa

Detalles Bibliográficos
Autores principales: Griffin, Percy, Sheehan, Patrick W, Dimitry, Julie M, Guo, Chun, Kanan, Michael F, Lee, Jiyeon, Zhang, Jinsong, Musiek, Erik S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728439/
https://www.ncbi.nlm.nih.gov/pubmed/33258449
http://dx.doi.org/10.7554/eLife.58765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728439/
https://www.ncbi.nlm.nih.gov/pubmed/33258449
http://dx.doi.org/10.7554/eLife.58765

Ejemplares similares