Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies and links the major pathways by which mutations inactivate p53. We find that DBD possesses two unusual properties—one of the highest zinc affi...

Descripción completa

Detalles Bibliográficos
Autores principales: Blanden, Adam R, Yu, Xin, Blayney, Alan J, Demas, Christopher, Ha, Jeung-Hoi, Liu, Yue, Withers, Tracy, Carpizo, Darren R, Loh, Stewart N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728444/
https://www.ncbi.nlm.nih.gov/pubmed/33263541
http://dx.doi.org/10.7554/eLife.61487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728444/
https://www.ncbi.nlm.nih.gov/pubmed/33263541
http://dx.doi.org/10.7554/eLife.61487

Ejemplares similares