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Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies and links the major pathways by which mutations inactivate p53. We find that DBD possesses two unusual properties—one of the highest zinc affi...

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Detalles Bibliográficos
Autores principales:	Blanden, Adam R, Yu, Xin, Blayney, Alan J, Demas, Christopher, Ha, Jeung-Hoi, Liu, Yue, Withers, Tracy, Carpizo, Darren R, Loh, Stewart N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728444/ https://www.ncbi.nlm.nih.gov/pubmed/33263541 http://dx.doi.org/10.7554/eLife.61487

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