Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1

Diabetic nephropathy (DN), a microvascular complication of diabetes, is the leading cause of end-stage renal disease worldwide. Multiple studies have shown that podocyte dysfunction is a central event in the progression of the disease. Beside chronic hyperglycemia, dyslipidemia can induce insulin re...

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Detalles Bibliográficos
Autores principales: Denhez, Benoit, Rousseau, Marina, Spino, Crysta, Dancosst, David-Alexandre, Dumas, Marie-Ève, Guay, Andréanne, Lizotte, Farah, Geraldes, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728775/
https://www.ncbi.nlm.nih.gov/pubmed/33303821
http://dx.doi.org/10.1038/s41598-020-78376-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728775/
https://www.ncbi.nlm.nih.gov/pubmed/33303821
http://dx.doi.org/10.1038/s41598-020-78376-1

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