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Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit
Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP(Sc)), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms. Work in multiple biological m...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729027/ https://www.ncbi.nlm.nih.gov/pubmed/33234071 http://dx.doi.org/10.1098/rsob.200282 |