Unravelling the intricate cooperativity of subunit gating in P2X2 ion channels

Ionotropic purinergic (P2X) receptors are trimeric channels that are activated by the binding of ATP. They are involved in multiple physiological functions, including synaptic transmission, pain and inflammation. The mechanism of activation is still elusive. Here we kinetically unraveled and quantif...

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Detalles Bibliográficos
Autores principales: Sattler, Christian, Eick, Thomas, Hummert, Sabine, Schulz, Eckhard, Schmauder, Ralf, Schweinitz, Andrea, Unzeitig, Christopher, Schwede, Frank, Benndorf, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729398/
https://www.ncbi.nlm.nih.gov/pubmed/33303878
http://dx.doi.org/10.1038/s41598-020-78672-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729398/
https://www.ncbi.nlm.nih.gov/pubmed/33303878
http://dx.doi.org/10.1038/s41598-020-78672-w

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