An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (S)-5-(tert-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid

A catalytic and enantioselective preparation of the (S)-4-methyleneproline scaffold is described. The key reaction is a one-pot double allylic alkylation of an imine analogue of glycine in the presence of a chinchonidine-derived catalyst under phase transfer conditions. These 4-methylene substituted...

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Detalles Bibliográficos
Autores principales: López, Blanca, Bartra, Martí, Berenguer, Ramon, Ariza, Xavier, Garcia, Jordi, Gómez, Roberto, Torralvo, Hèctor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729483/
https://www.ncbi.nlm.nih.gov/pubmed/33266105
http://dx.doi.org/10.3390/molecules25235644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729483/
https://www.ncbi.nlm.nih.gov/pubmed/33266105
http://dx.doi.org/10.3390/molecules25235644

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