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Modulation of Amyloidogenic Protein Self-Assembly Using Tethered Small Molecules

[Image: see text] Protein–protein interactions (PPIs) are involved in many of life’s essential biological functions yet are also an underlying cause of several human diseases, including amyloidosis. The modulation of PPIs presents opportunities to gain mechanistic insights into amyloid assembly, par...

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Detalles Bibliográficos
Autores principales: Cawood, Emma E., Guthertz, Nicolas, Ebo, Jessica S., Karamanos, Theodoros K., Radford, Sheena E., Wilson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7729939/
https://www.ncbi.nlm.nih.gov/pubmed/33253560
http://dx.doi.org/10.1021/jacs.0c10629