Cargando…

A One-Pot Three-Component Synthesis and Investigation of the In Vitro Mechanistic Anticancer Activity of Highly Functionalized Spirooxindole-Pyrrolidine Heterocyclic Hybrids

With an aim to develop more effective and affordable anticancer agents possessing a unique mechanism of action, we designed and synthesized derivatives of spirooxindole-pyrrolidine heterocyclic hybrids in good yields through a one-pot three-component (3+2) cycloaddition strategy. The synthesized com...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Raju Suresh, M. Al-thamili, Dhaifallah, Almansour, Abdulrahman I., Arumugam, Natarajan, Mohammad, Faruq
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730040/ https://www.ncbi.nlm.nih.gov/pubmed/33261115 http://dx.doi.org/10.3390/molecules25235581

Ejemplares similares

[Bmim]Br Accelerated One-Pot Three-Component Cascade Protocol for the Construction of Spirooxindole–Pyrrolidine Heterocyclic Hybrids
por: Kumar, Raju Suresh, et al.
Publicado: (2020)

In vitro Mechanistic Exploration of Novel Spiropyrrolidine Heterocyclic Hybrids as Anticancer Agents
por: Kumar, Raju Suresh, et al.
Publicado: (2020)

Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol
por: Arumugam, Natarajan, et al.
Publicado: (2018)

Design, Synthesis and In Vitro Mechanistic Investigation of Novel Hexacyclic Cage-Like Hybrid Heterocycles
por: Kumar, Raju Suresh, et al.
Publicado: (2019)

Domino Multicomponent Approach for the Synthesis of Functionalized Spiro-Indeno[1,2-b]quinoxaline Heterocyclic Hybrids and Their Antimicrobial Activity, Synergistic Effect and Molecular Docking Simulation
por: Almansour, Abdulrahman I., et al.
Publicado: (2019)

A Novel One-Pot Green Synthesis of Dispirooxindolo-pyrrolidines via1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides
por: Almansour, Abdulrahman I., et al.
Publicado: (2015)

Environmentally friendly domino multicomponent strategy for the synthesis of pyrroloquinolinone hybrid heterocycles
por: Mani, Suresh, et al.
Publicado: (2022)

Caspase dependent apoptotic activity of polycyclic cage-like heterocyclic hybrids
por: Kumar, Raju Suresh, et al.
Publicado: (2020)

Cholinesterase inhibitory activity of highly functionalized fluorinated spiropyrrolidine heterocyclic hybrids
por: Kumar, Raju Suresh, et al.
Publicado: (2021)

Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines
por: Arumugam, Natarajan, et al.
Publicado: (2018)

Highly functionalized pyrrolidine analogues: stereoselective synthesis and caspase-dependent apoptotic activity
por: Kumar, Raju Suresh, et al.
Publicado: (2018)

An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction
por: Arumugam, Natarajan, et al.
Publicado: (2015)

A New Class of β–Pyrrolidino-1,2,3-Triazole Derivatives as β-Adrenergic Receptor Inhibitors: Synthesis, Pharmacological, and Docking Studies
por: Easwaramoorthi, Kaliyappan, et al.
Publicado: (2019)

Regio- and diastereoselective synthesis of spiropyrroloquinoxaline grafted indole heterocyclic hybrids and evaluation of their anti-Mycobacterium tuberculosis activity
por: Arumugam, Natarajan, et al.
Publicado: (2020)

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold
por: Panda, Siva S., et al.
Publicado: (2023)

Green synthesis of new pyrrolidine-fused spirooxindoles via three-component domino reaction in EtOH/H(2)O
por: Wang, Yong-Chao, et al.
Publicado: (2018)

D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity
por: Almansour, Abdulrahman I., et al.
Publicado: (2019)

5-Chlorospiro[indoline-3,7′-6H,7H,8H-pyrano[3,2-c:5,6-c′]di[1]benzopyran]-2,6′,8′-trione
por: Almansour, Abdulrahman I., et al.
Publicado: (2012)

Facile one-pot, multi-component reaction to synthesize spirooxindole-annulated thiopyran derivatives under environmentally benevolent conditions
por: Matloubi Moghaddam, F., et al.
Publicado: (2022)

5-Methylspiro[indoline-3,7′-[6H,7H,8H]pyrano[3,2-c:5,6-c′]di[1]benzopyran]-2,6′,8′-trione chloroform hemisolvate
por: Almansour, Abdulrahman I., et al.
Publicado: (2012)

2-Hydroxy-5-[(E)-2-methylbenzylidene]-8-(2-methylphenyl)-9-phenyl-3,10-diazahexacyclo[10.7.1.1(3,7).0(2,11).0(7,11).0(16,20)]henicosa-1(20),12,14,16,18-pentaen-6-one
por: Almansour, Abdulrahman I., et al.
Publicado: (2012)

(3E,5E)-1-Allyl-3,5-bis(4-methoxybenzylidene)piperidin-4-one
por: Almansour, Abdulrahman I., et al.
Publicado: (2013)

9-(2-Chlorobenzylidene)anthracen-10(9H)-one
por: Almansour, Abdulrahman I., et al.
Publicado: (2013)

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents
por: Wu, Liqiang, et al.
Publicado: (2018)

5-Fluoro-6′H,7′H,8′H-spiro[indoline-3,7′-pyrano[3,2-c:5,6-c′]di-1-benzopyran]-2,6′,8′-trione
por: Almansour, Abdulrahman I., et al.
Publicado: (2012)

Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process
por: Muthu, Muthumani, et al.
Publicado: (2018)

Discovery of diazahexa/hepta cyclic cage-like compounds with broad-spectrum antifungal activity against Candida and Cryptococcus species
por: Weinstock, Anthony, et al.
Publicado: (2019)

Efficient Synthesis of Fully Substituted Pyrrolidine-Fused 3-Spirooxindoles via 1,3-Dipolar Cycloaddition of Aziridine and 3-Ylideneoxindole
por: Ren, Wen, et al.
Publicado: (2016)

Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1
por: Barakat, Assem, et al.
Publicado: (2018)

Stereoselective Synthesis of Spirooxindole Derivatives Using One-Pot Multicomponent Cycloaddition Reaction and Evaluation of Their Antiproliferative Efficacy
por: Ghosh, Rajat, et al.
Publicado: (2020)

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells
por: Eldehna, Wagdy M., et al.
Publicado: (2017)

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines
por: Song, Qiao, et al.
Publicado: (2022)

An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines
por: Almansour, Abdulrahman I., et al.
Publicado: (2015)

Synthesis of new functionalized thiazolo pyridine-fused and thiazolo pyridopyrimidine-fused spirooxindoles via one-pot reactions
por: Nasri, Shima, et al.
Publicado: (2020)

Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities
por: Almansour, Abdulrahman I., et al.
Publicado: (2014)

A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid
por: Suresh Kumar, Raju, et al.
Publicado: (2016)

Synthesis, Spectroscopic, X-ray Diffraction and DFT Studies of Novel Benzimidazole Fused-1,4-Oxazepines
por: Almansour, Abdulrahman I., et al.
Publicado: (2016)

Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents
por: Al-Majid, Abdullah Mohammed, et al.
Publicado: (2021)

1′′-Allyl-5′′-(4-methoxybenzylidene)-7′-(4-methoxyphenyl)-1′,3′,5′,6′,7′,7a′-hexahydrodispiro[acenaphthylene-1,5′-pyrrolo[1,2-c][1,3]thiazole-6′,3′′-piperidine]-2,4′′(1H)-dione
por: Almansour, Abulrahman I., et al.
Publicado: (2013)

Transition metal-catalyzed synthesis of spirooxindoles
por: Saranya, P. V., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bdqfnup89h4rccn30ugno4dmd0