RB Regulates DNA Double Strand Break Repair Pathway Choice by Mediating CtIP Dependent End Resection

Inactivation of the retinoblastoma tumor suppressor gene (RB1) leads to genome instability, and can be detected in retinoblastoma and other cancers. One damaging effect is causing DNA double strand breaks (DSB), which, however, can be repaired by homologous recombination (HR), classical non-homologo...

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Detalles Bibliográficos
Autores principales: Jiang, Yuning, Yam, Jason C., Tham, Clement C., Pang, Chi Pui, Chu, Wai Kit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730402/
https://www.ncbi.nlm.nih.gov/pubmed/33271982
http://dx.doi.org/10.3390/ijms21239176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730402/
https://www.ncbi.nlm.nih.gov/pubmed/33271982
http://dx.doi.org/10.3390/ijms21239176

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