Design, Synthesis and Evaluation of New Bioactive Oxadiazole Derivatives as Anticancer Agents Targeting Bcl-2

A series of 2-(1H-indol-3-yl)-5-substituted-1,3,4-oxadiazoles, 4a–m, were designed, synthesized and tested in vitro as potential pro-apoptotic Bcl-2 inhibitory anticancer agents based on our previously reported hit compounds. Synthesis of the target 1,3,4-oxadiazoles was readily accomplished through...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamdy, Rania, Elseginy, Samia A., Ziedan, Noha I., El-Sadek, Mohamed, Lashin, Elsaid, Jones, Arwyn T., Westwell, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730549/
https://www.ncbi.nlm.nih.gov/pubmed/33256166
http://dx.doi.org/10.3390/ijms21238980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730549/
https://www.ncbi.nlm.nih.gov/pubmed/33256166
http://dx.doi.org/10.3390/ijms21238980

Ejemplares similares