Grignard Reagent Utilization Enables a Practical and Scalable Construction of 3-Substituted 5-Chloro-1,6-naphthyridin-4-one Derivatives

A robust, practical, and scalable approach for the construction of 3-substituted 5-chloro-1,6-naphthyridin-4-one derivatives 13 via the addition of Grignard reagents to 4-amino-2-chloronicotinonitrile (15) was developed. Starting with various Grignard reagents, a wide range of 3-substituted 5-chloro...

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Detalles Bibliográficos
Autores principales: Wang, Ming-Shu, Gong, Yi, Yu, Zhi-Cheng, Tian, Yan-Guang, Zhuo, Lin-Sheng, Huang, Wei, She, Neng-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730554/
https://www.ncbi.nlm.nih.gov/pubmed/33271818
http://dx.doi.org/10.3390/molecules25235667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730554/
https://www.ncbi.nlm.nih.gov/pubmed/33271818
http://dx.doi.org/10.3390/molecules25235667

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