PTEN and Other PtdIns(3,4,5)P(3) Lipid Phosphatases in Breast Cancer

The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is hyperactivated in ~70% of breast cancers. Class I PI3K generates PtdIns(3,4,5)P(3) at the plasma membrane in response to growth factor stimulation, leading to AKT activation to drive cell proliferation, survival and migration. PTEN negat...

Descripción completa

Detalles Bibliográficos
Autores principales: Csolle, Mariah P., Ooms, Lisa M., Papa, Antonella, Mitchell, Christina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730566/
https://www.ncbi.nlm.nih.gov/pubmed/33276499
http://dx.doi.org/10.3390/ijms21239189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730566/
https://www.ncbi.nlm.nih.gov/pubmed/33276499
http://dx.doi.org/10.3390/ijms21239189

Ejemplares similares