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PTEN and Other PtdIns(3,4,5)P(3) Lipid Phosphatases in Breast Cancer

The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is hyperactivated in ~70% of breast cancers. Class I PI3K generates PtdIns(3,4,5)P(3) at the plasma membrane in response to growth factor stimulation, leading to AKT activation to drive cell proliferation, survival and migration. PTEN negat...

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Detalles Bibliográficos
Autores principales:	Csolle, Mariah P., Ooms, Lisa M., Papa, Antonella, Mitchell, Christina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730566/ https://www.ncbi.nlm.nih.gov/pubmed/33276499 http://dx.doi.org/10.3390/ijms21239189

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