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Mutational Analysis of the Nsa2 N-Terminus Reveals Its Essential Role in Ribosomal 60S Subunit Assembly

The ribosome assembly factor Nsa2 is part of the Rea1-Rsa4-Nsa2 interconnected relay on nuclear pre-60S particles that is essential for 60S ribosome biogenesis. Cryo-EM structures depict Nsa2 docked via its C-terminal β-barrel domain to nuclear pre-60S particles, whereas the extended N-terminus, con...

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Detalles Bibliográficos
Autores principales:	Paternoga, Helge, Früh, Alexander, Kunze, Ruth, Bradatsch, Bettina, Baßler, Jochen, Hurt, Ed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730687/ https://www.ncbi.nlm.nih.gov/pubmed/33266193 http://dx.doi.org/10.3390/ijms21239108

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