Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency

Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid lappaconitine and pyrimidine fragments are reported. One route takes place via first converting of lappaconitine to 1-ethynyl-lappaconitine, followed by the Sonogashira cross-coupling-cyclocondensation sequen...

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Detalles Bibliográficos
Autores principales: Cheremnykh, Kirill P., Savelyev, Victor A., Borisov, Sergey A., Ivanov, Igor D., Baev, Dmitry S., Tolstikova, Tatyana G., Vavilin, Valentin A., Shults, Elvira E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730767/
https://www.ncbi.nlm.nih.gov/pubmed/33261161
http://dx.doi.org/10.3390/molecules25235578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730767/
https://www.ncbi.nlm.nih.gov/pubmed/33261161
http://dx.doi.org/10.3390/molecules25235578

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