Cargando…

Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency

Convenient and efficient routes to construct hybrid molecules containing diterpene alkaloid lappaconitine and pyrimidine fragments are reported. One route takes place via first converting of lappaconitine to 1-ethynyl-lappaconitine, followed by the Sonogashira cross-coupling-cyclocondensation sequen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheremnykh, Kirill P., Savelyev, Victor A., Borisov, Sergey A., Ivanov, Igor D., Baev, Dmitry S., Tolstikova, Tatyana G., Vavilin, Valentin A., Shults, Elvira E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730767/ https://www.ncbi.nlm.nih.gov/pubmed/33261161 http://dx.doi.org/10.3390/molecules25235578

Ejemplares similares

Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine–1,5-Benzodiazepine Hybrids
por: Cheremnykh, Kirill P., et al.
Publicado: (2023)

Design, Synthesis and Assay of Novel Methylxanthine–Alkynylmethylamine Derivatives as Acetylcholinesterase Inhibitors
por: Reshetnikov, Danila V., et al.
Publicado: (2022)

Synthesis of Anti-Inflammatory Spirostene-Pyrazole Conjugates by a Consecutive Multicomponent Reaction of Diosgenin with Oxalyl Chloride, Arylalkynes and Hydrazines or Hydrazones
por: Mironov, Maksim E., et al.
Publicado: (2021)

Analgesic effects of lappaconitine in leukemia bone pain in a mouse model
por: Zhu, Xiao-Cui, et al.
Publicado: (2015)

2-Amino-4,6-dimethylpyrimidine–anthranilic acid (1/1)
por: Ebenezer, Samuel, et al.
Publicado: (2010)

A Metabolomic Study of the Analgesic Effect of Lappaconitine Hydrobromide (LAH) on Inflammatory Pain
por: Li, Xu, et al.
Publicado: (2022)

Cascade Transformations of 1-R-Ethynyl-9,10-anthraquinones with Amidines: Expanding Access to Isoaporphinoid Alkaloids
por: Vasilevsky, Sergey Francevich, et al.
Publicado: (2021)

Engineering of Saccharomyces cerevisiae for anthranilate and methyl anthranilate production
por: Kuivanen, Joosu, et al.
Publicado: (2021)

Glucosyl anthranilate
por: Liu, Haoyan, et al.
Publicado: (2009)

Quantification of Lappaconitine in Mouse Blood by UPLC-MS/MS and Its Application to a Pharmacokinetic Study
por: Chen, Fan, et al.
Publicado: (2019)

Synthesis, in vitro and in vivo biological evaluation of novel lappaconitine derivatives as potential anti-inflammatory agents
por: Pang, Lei, et al.
Publicado: (2020)

Hydrogen-bonding patterns in the cocrystal 2-amino-4,6-dimethoxypyrimidine–anthranilic acid (1/1)
por: Thanigaimani, Kaliyaperumal, et al.
Publicado: (2007)

Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine
por: Cavalcante-Silva, Luiz Henrique Agra, et al.
Publicado: (2014)

1-Hydroxyanthraquinones Containing Aryl Substituents as Potent and Selective Anticancer Agents
por: Sirazhetdinova, Nafisa S., et al.
Publicado: (2020)

Influence of Aromatic and Aliphatic Moieties on Thrombin Inhibitors Potency
por: Poyarkov, Alexey, et al.
Publicado: (2008)

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus
por: Dyniewicz, Jolanta, et al.
Publicado: (2020)

Synthesis and Antifungal Activity of Pyrimidine Derivatives Containing an Amide Moiety
por: Wu, Wenneng, et al.
Publicado: (2021)

N-Phenylanthranilic anhydride
por: Liu, Guan-Feng, et al.
Publicado: (2009)

Microbial-Derived Tryptophan Metabolites and Their Role in Neurological Disease: Anthranilic Acid and Anthranilic Acid Derivatives
por: Shaw, Claire, et al.
Publicado: (2023)

Synthesis of indole derivatives as prevalent moieties present in selected alkaloids
por: Heravi, Majid M., et al.
Publicado: (2021)

Structure, mechanism and inhibition of anthranilate phosphoribosyltransferase
por: Scully, Thomas W., et al.
Publicado: (2023)

Antinociceptive and Anti-Inflammatory Effects of Total Alkaloid Extract from Fumaria capreolata
por: Bribi, Noureddine, et al.
Publicado: (2015)

Betulinic Acid-Azaprostanoid Hybrids: Synthesis and Pharmacological Evaluation as Anti-inflammatory Agents
por: Khlebnicova, Tatyana S., et al.
Publicado: (2020)

Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents
por: Venkatesh, Talavara, et al.
Publicado: (2018)

Design, Synthesis, and Bioactivities of Novel Trifluoromethyl Pyrimidine Derivatives Bearing an Amide Moiety
por: Lan, Wenjun, et al.
Publicado: (2022)

Design, Synthesis and Bioactivity of Novel Pyrimidine Sulfonate Esters Containing Thioether Moiety
por: Li, Changkun, et al.
Publicado: (2023)

Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists
por: Azevedo Neto, Joaquim, et al.
Publicado: (2021)

3-Hydroxi-Anthranilic Acid is Early Expressed in Stroke
por: Mangas, A., et al.
Publicado: (2016)

Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors
por: Halawa, Ahmed H., et al.
Publicado: (2019)

Antinociceptive effect of methanolic extract and alkaloid fractions of Berberis integerrima root in animal models
por: Hajhashemi, Valiollah, et al.
Publicado: (2018)

Synthesis and Biological Evaluation of Novel Pyrimidine Amine Derivatives Bearing Bicyclic Monoterpene Moieties
por: Zhang, Mingguang, et al.
Publicado: (2022)

Synthesis, Antifungal, and Antibacterial Activities of Novel Benzoylurea Derivatives Containing a Pyrimidine Moiety
por: An, Jiansong, et al.
Publicado: (2023)

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates
por: Østergaard, Michael E, et al.
Publicado: (2019)

On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio
por: Darlington, L. Gail, et al.
Publicado: (2010)

Production of hydroxycinnamoyl anthranilates from glucose in Escherichia coli
por: Eudes, Aymerick, et al.
Publicado: (2013)

Investigation on biological activities of anthranilic acid sulfonamide analogs
por: Doungsoongnuen, Sutanun, et al.
Publicado: (2011)

Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies
por: Nawaz, Muhammad, et al.
Publicado: (2022)

Electrooxidative Hofmann Rearrangement of Phthalimides to Access Anthranilate Derivatives
por: Wang, Jie, et al.
Publicado: (2023)

Quinoline Alkaloids Isolated from Choisya Aztec-Pearl and Their Contribution to the Overall Antinociceptive Activity of This Plant
por: de Carvalho, Patricia Ribeiro, et al.
Publicado: (2016)

Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues
por: Andreeva, Olga V., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lrt3n6970qrsk346qlk0i63qfa