Selective Binding of Cyclodextrins with Leflunomide and Its Pharmacologically Active Metabolite Teriflunomide

The selectivity of encapsulation of leflunomide and teriflunomide by native α-, β- and γ-cyclodextrins was investigated through (1)H NMR and molecular modeling. Thermodynamic analysis revealed the main driving forces involved in the binding. For α-cyclodextrin, the partial encapsulation was obtained...

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Detalles Bibliográficos
Autores principales: Terekhova, Irina, Kritskiy, Iliya, Agafonov, Mikhail, Kumeev, Roman, Martínez-Cortés, Carlos, Pérez-Sánchez, Horacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730839/
https://www.ncbi.nlm.nih.gov/pubmed/33265979
http://dx.doi.org/10.3390/ijms21239102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730839/
https://www.ncbi.nlm.nih.gov/pubmed/33265979
http://dx.doi.org/10.3390/ijms21239102

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