Effectiveness in Block by Dexmedetomidine of Hyperpolarization-Activated Cation Current, Independent of Its Agonistic Effect on α(2)-Adrenergic Receptors

Dexmedetomidine (DEX), a highly selective agonist of α(2)-adrenergic receptors, has been tailored for sedation without risk of respiratory depression. Our hypothesis is that DEX produces any direct perturbations on ionic currents (e.g., hyperpolarization-activated cation current, I(h)). In this stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Te-Ling, Lu, Te-Jung, Wu, Sheng-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730867/
https://www.ncbi.nlm.nih.gov/pubmed/33266068
http://dx.doi.org/10.3390/ijms21239110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730867/
https://www.ncbi.nlm.nih.gov/pubmed/33266068
http://dx.doi.org/10.3390/ijms21239110

Ejemplares similares