Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications

Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-ph...

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Detalles Bibliográficos
Autores principales: Lloyd, Carissa M., Colgin, Neil, Cobb, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730879/
https://www.ncbi.nlm.nih.gov/pubmed/33260551
http://dx.doi.org/10.3390/molecules25235601
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author Lloyd, Carissa M.
Colgin, Neil
Cobb, Steven L.
author_facet Lloyd, Carissa M.
Colgin, Neil
Cobb, Steven L.
author_sort Lloyd, Carissa M.
collection PubMed
description Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry.
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spelling pubmed-77308792020-12-12 Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications Lloyd, Carissa M. Colgin, Neil Cobb, Steven L. Molecules Review Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry. MDPI 2020-11-28 /pmc/articles/PMC7730879/ /pubmed/33260551 http://dx.doi.org/10.3390/molecules25235601 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lloyd, Carissa M.
Colgin, Neil
Cobb, Steven L.
Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications
title Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications
title_full Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications
title_fullStr Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications
title_full_unstemmed Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications
title_short Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications
title_sort current synthetic routes to peptidyl mono-fluoromethyl ketones (fmks) and their applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730879/
https://www.ncbi.nlm.nih.gov/pubmed/33260551
http://dx.doi.org/10.3390/molecules25235601
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