Discovery of Novel Dual Extracellular Regulated Protein Kinases (ERK) and Phosphoinositide 3-Kinase (PI3K) Inhibitors as a Promising Strategy for Cancer Therapy

Concomitant inhibition of MAPK and PI3K signaling pathways has been recognized as a promising strategy for cancer therapy, which effectively overcomes the drug resistance of MAPK signaling pathway-related inhibitors. Herein, we report the scaffold-hopping generation of a series of 1H-pyrazolo[3,4-d]...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Lingzhi, Ju, Qiurong, Sun, Jinjin, Huang, Lei, Wu, Shiqi, Wang, Shuping, Li, Yin, Guan, Zhe, Zhu, Qihua, Xu, Yungen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730961/
https://www.ncbi.nlm.nih.gov/pubmed/33287111
http://dx.doi.org/10.3390/molecules25235693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730961/
https://www.ncbi.nlm.nih.gov/pubmed/33287111
http://dx.doi.org/10.3390/molecules25235693

Ejemplares similares