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The Gαi protein subclass selectivity to the dopamine D(2) receptor is also decided by their location at the cell membrane
BACKGROUND: G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins plays an important role in the cellular regulation of responses to external stimuli. Despite intensive structural research, the mechanism underlying the receptor–G protein coupling of closely related subtypes of Gα...
Autores principales: | Polit, Agnieszka, Rysiewicz, Beata, Mystek, Paweł, Błasiak, Ewa, Dziedzicka-Wasylewska, Marta |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731117/ https://www.ncbi.nlm.nih.gov/pubmed/33308256 http://dx.doi.org/10.1186/s12964-020-00685-9 |
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