Description of a Novel Mechanism Possibly Explaining the Antiproliferative Properties of Glucocorticoids in Duchenne Muscular Dystrophy Fibroblasts Based on Glucocorticoid Receptor GR and NFAT5

Glucocorticoids are drugs of choice in Duchenne muscular dystrophy (DMD), prolonging patients’ ambulation. Their mode of action at the protein level is not completely understood. In DMD, muscle tissue is replaced by fibrotic tissue produced by fibroblasts, reducing mobility. Nuclear factor of activa...

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Detalles Bibliográficos
Autores principales: Herbelet, Sandrine, De Paepe, Boel, De Bleecker, Jan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731298/
https://www.ncbi.nlm.nih.gov/pubmed/33287327
http://dx.doi.org/10.3390/ijms21239225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731298/
https://www.ncbi.nlm.nih.gov/pubmed/33287327
http://dx.doi.org/10.3390/ijms21239225

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