Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies

A new series of hybrid compounds with tropinone and thiazole rings in the structure was designed and synthesized as potential anticancer agents. They were tested against human multiple myeloma (RPMI 8226), lung carcinoma (A549), breast adenocarcinoma (MDA-MB-231), and mouse skin melanoma (B16-F10) c...

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Detalles Bibliográficos
Autores principales: Piechowska, Katarzyna, Mizerska-Kowalska, Magdalena, Zdzisińska, Barbara, Cytarska, Joanna, Baranowska-Łączkowska, Angelika, Jaroch, Karol, Łuczykowski, Kamil, Płaziński, Wojciech, Bojko, Barbara, Kruszewski, Stefan, Misiura, Konrad, Łączkowski, Krzysztof Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731314/
https://www.ncbi.nlm.nih.gov/pubmed/33260768
http://dx.doi.org/10.3390/ijms21239050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731314/
https://www.ncbi.nlm.nih.gov/pubmed/33260768
http://dx.doi.org/10.3390/ijms21239050

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