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MCL-1 inhibitors, fast-lane development of a new class of anti-cancer agents
Cell death escape is one of the most prominent features of tumor cells and closely linked to the dysregulation of members of the Bcl-2 family of proteins. Among those, the anti-apoptotic family member myeloid cell leukemia-1 (MCL-1) acts as a master regulator of apoptosis in various human malignanci...
Autores principales: | Bolomsky, Arnold, Vogler, Meike, Köse, Murat Cem, Heckman, Caroline A., Ehx, Grégory, Ludwig, Heinz, Caers, Jo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731749/ https://www.ncbi.nlm.nih.gov/pubmed/33308268 http://dx.doi.org/10.1186/s13045-020-01007-9 |
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