Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes

The transcriptional coregulator OCA-B promotes expression of T cell target genes in cases of repeated antigen exposure, a necessary feature of autoimmunity. We hypothesized that T cell–specific OCA-B deletion and pharmacologic OCA-B inhibition would protect mice from autoimmune diabetes. We develope...

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Detalles Bibliográficos
Autores principales: Kim, Heejoo, Perovanovic, Jelena, Shakya, Arvind, Shen, Zuolian, German, Cody N., Ibarra, Andrea, Jafek, Jillian L., Lin, Nai-Pin, Evavold, Brian D., Chou, Danny H.-C., Jensen, Peter E., He, Xiao, Tantin, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731945/
https://www.ncbi.nlm.nih.gov/pubmed/33295943
http://dx.doi.org/10.1084/jem.20200533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731945/
https://www.ncbi.nlm.nih.gov/pubmed/33295943
http://dx.doi.org/10.1084/jem.20200533

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