Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening

Calmodulin (CaM) and phosphatidylinositol 4,5-bisphosphate (PIP(2)) are potent regulators of the voltage-gated potassium channel KCNQ1 (K(V)7.1), which conducts the cardiac I(Ks) current. Although cryo–electron microscopy structures revealed intricate interactions between the KCNQ1 voltage-sensing d...

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Detalles Bibliográficos
Autores principales: Kang, Po Wei, Westerlund, Annie M., Shi, Jingyi, White, Kelli McFarland, Dou, Alex K., Cui, Amy H., Silva, Jonathan R., Delemotte, Lucie, Cui, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732179/
https://www.ncbi.nlm.nih.gov/pubmed/33310856
http://dx.doi.org/10.1126/sciadv.abd6798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732179/
https://www.ncbi.nlm.nih.gov/pubmed/33310856
http://dx.doi.org/10.1126/sciadv.abd6798

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