Knockdown of NHP2 inhibits hepatitis B virus X protein-induced hepatocarcinogenesis via repressing TERT expression and disrupting the stability of telomerase complex

Hepatitis B virus X protein (HBx) is highly expressed in HBV-infected hepatocellular carcinoma (HCC) and upregulates transcriptional activation of telomerase reverse transcriptase (TERT). NHP2 is a component of the telomerase complex and also increased in HCC. However, whether NHP2 could accelerate...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Shuming, Wu, Weigang, Wan, Haoqiang, Wu, Xuecheng, Chen, Haixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732313/
https://www.ncbi.nlm.nih.gov/pubmed/33044946
http://dx.doi.org/10.18632/aging.103810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732313/
https://www.ncbi.nlm.nih.gov/pubmed/33044946
http://dx.doi.org/10.18632/aging.103810

Ejemplares similares