Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice

Aging is an independent risk factor for cardiovascular diseases, such as myocardial infarction due to ischemia-reperfusion injury (I/R) of the heart. Cytosolic thioredoxin (Trx) is a multifunctional redox protein which has antioxidant and protein disulfide reducing properties. We hypothesized that h...

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Detalles Bibliográficos
Autores principales: Subramani, Jaganathan, Kundumani-Sridharan, Venkatesh, Das, Kumuda C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732314/
https://www.ncbi.nlm.nih.gov/pubmed/33049718
http://dx.doi.org/10.18632/aging.104071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732314/
https://www.ncbi.nlm.nih.gov/pubmed/33049718
http://dx.doi.org/10.18632/aging.104071

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