Cargando…

Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice

Aging is an independent risk factor for cardiovascular diseases, such as myocardial infarction due to ischemia-reperfusion injury (I/R) of the heart. Cytosolic thioredoxin (Trx) is a multifunctional redox protein which has antioxidant and protein disulfide reducing properties. We hypothesized that h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Subramani, Jaganathan, Kundumani-Sridharan, Venkatesh, Das, Kumuda C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732314/ https://www.ncbi.nlm.nih.gov/pubmed/33049718 http://dx.doi.org/10.18632/aging.104071

Ejemplares similares

Nrg1β Released in Remote Ischemic Preconditioning Improves Myocardial Perfusion and Decreases Ischemia/Reperfusion Injury via ErbB2-Mediated Rescue of Endothelial Nitric Oxide Synthase and Abrogation of Trx2 Autophagy
por: Kundumani-Sridharan, Venkatesh, et al.
Publicado: (2021)

Mechanism of PGC-1α-mediated mitochondrial biogenesis in cerebral ischemia–reperfusion injury
por: Yuan, Ying, et al.
Publicado: (2023)

Melatonin improves mitochondrial biogenesis through the AMPK/PGC1α pathway to attenuate ischemia/reperfusion-induced myocardial damage
por: Qi, Xueyan, et al.
Publicado: (2020)

3-Bromo-4,5-Dihydroxybenzaldehyde Protects Against Myocardial Ischemia and Reperfusion Injury Through the Akt-PGC1α-Sirt3 Pathway
por: Qin, Shu-Guang, et al.
Publicado: (2018)

Thioredoxin-1 Promotes Mitochondrial Biogenesis Through Regulating AMPK/Sirt1/PGC1α Pathway in Alzheimer's Disease
por: Jia, Jinjing, et al.
Publicado: (2023)

LATS2 Deletion Attenuates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Biogenesis
por: Chen, Yi, et al.
Publicado: (2021)

Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats
por: Li, Lingyu, et al.
Publicado: (2016)

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia
por: Chen, Shang-Der, et al.
Publicado: (2011)

Role of cytokines in myocardial ischemia and reperfusion
por: Sharma, H. S., et al.
Publicado: (1997)

Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway
por: Zhu, Ting, et al.
Publicado: (2021)

Retracted: LATS2 Deletion Attenuates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Biogenesis
por: Longevity, Oxidative Medicine and Cellular
Publicado: (2023)

Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion
por: Penela, Petronila, et al.
Publicado: (2019)

Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition via CREB/PGC-1α Pathway
por: Guan, Xin, et al.
Publicado: (2019)

MicroRNAs in the regulation of cellular redox status and its implications in myocardial ischemia-reperfusion injury
por: Carbonell, Teresa, et al.
Publicado: (2020)

Redox Regulatory Mechanism of Transnitrosylation by Thioredoxin
por: Wu, Changgong, et al.
Publicado: (2010)

Taurine promotes cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1α pathway
por: Jia, Ning, et al.
Publicado: (2016)

Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways
por: Lin, Fei, et al.
Publicado: (2020)

Reperfusion Promotes Mitochondrial Biogenesis following Focal Cerebral Ischemia in Rats
por: Xie, Yuying, et al.
Publicado: (2014)

Geranylgeranylacetone Ameliorates Skin Inflammation by Regulating and Inducing Thioredoxin via the Thioredoxin Redox System
por: Jin, Tiancheng, et al.
Publicado: (2023)

Redox-dependent and redox-independent functions of Caenorhabditis elegans thioredoxin 1
por: Sanzo-Machuca, Ángela, et al.
Publicado: (2019)

Hydrogen sulphide and mild hypothermia activate the CREB signaling pathway and prevent ischemia-reperfusion injury
por: Dai, Hai-bin, et al.
Publicado: (2015)

CREB1 and PPAR-α/γ Pathways in Hepatic Ischemia/Reperfusion: Route for Curcumin to Hepatoprotection
por: Demir, Enver Ahmet, et al.
Publicado: (2023)

Platelets in Myocardial Ischemia/Reperfusion Injury
por: Schanze, Nancy, et al.
Publicado: (2022)

The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases
por: Fontecha-Barriuso, Miguel, et al.
Publicado: (2020)

Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia
por: Nagarajan, Narayani, et al.
Publicado: (2023)

PGC‐1α protects from myocardial ischaemia‐reperfusion injury by regulating mitonuclear communication
por: Li, Yan‐Qing, et al.
Publicado: (2021)

Berberine attenuates myocardial ischemia reperfusion injury by suppressing the activation of PI3K/AKT signaling
por: QIN-WEI, ZHU, et al.
Publicado: (2016)

Thioredoxin and related redox systems as targets in breast cancer
por: Woolston, CM, et al.
Publicado: (2010)

Tuning of Thioredoxin Redox Properties by Intramolecular Hydrogen Bonds
por: Røhr, Åsmund Kjendseth, et al.
Publicado: (2013)

The mechanism by which miR-494-3p regulates PGC1-α-mediated inhibition of mitophagy in cardiomyocytes and alleviation of myocardial ischemia—reperfusion injury
por: Mu, Ninghui, et al.
Publicado: (2023)

Tregs biomimetic nanoparticle to reprogram inflammatory and redox microenvironment in infarct tissue to treat myocardial ischemia reperfusion injury in mice
por: Li, Fangyuan, et al.
Publicado: (2022)

Curcumin attenuates myocardial ischemia–reperfusion injury
por: Liu, Kun, et al.
Publicado: (2017)

Platelet Contributions to Myocardial Ischemia/Reperfusion Injury
por: Schanze, Nancy, et al.
Publicado: (2019)

Platelets, diabetes and myocardial ischemia/reperfusion injury
por: Russo, Isabella, et al.
Publicado: (2017)

Pentoxifylline Enhances Antioxidative Capability and Promotes Mitochondrial Biogenesis in D-Galactose-Induced Aging Mice by Increasing Nrf2 and PGC-1α through the cAMP-CREB Pathway
por: Wang, Yu, et al.
Publicado: (2021)

Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
por: Wang, Y., et al.
Publicado: (2013)

6-Gingerol Activates PI3K/Akt and Inhibits Apoptosis to Attenuate Myocardial Ischemia/Reperfusion Injury
por: Lv, Xiangwei, et al.
Publicado: (2018)

Piperine protects against myocardial ischemia/reperfusion injury by activating the PI3K/AKT signaling pathway
por: Li, Yun-Peng, et al.
Publicado: (2021)

Electroacupuncture Pretreatment Mitigates Myocardial Ischemia/Reperfusion Injury via XBP1/GRP78/Akt Pathway
por: Wang, Nisha, et al.
Publicado: (2021)

Procaspase-9 induces its cleavage by transnitrosylating XIAP via the Thioredoxin system during cerebral ischemia-reperfusion in rats
por: Zhang, Dengyue, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_lvak5jrju6nn4qhj5cicq8ric3