BRD4 inhibition sensitizes renal cell carcinoma cells to the PI3K/mTOR dual inhibitor VS-5584

Activation of the PI3K/AKT/mTOR pathway promotes the progression of renal cell carcinoma (RCC). This study tested the anti-RCC cell activity of the PI3K/mTOR dual inhibitor, VS-5584. We show that VS-5584 inhibited PI3K/AKT/mTORC1/2 activation in established (786-O and A498 lines) and primary RCC cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Ming, Xu, Lijun, Wang, Yin, Dai, Guangcheng, Xue, Boxin, Liu, Yuan-yuan, Zhu, Jianbing, Zhu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732329/
https://www.ncbi.nlm.nih.gov/pubmed/33051401
http://dx.doi.org/10.18632/aging.103723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732329/
https://www.ncbi.nlm.nih.gov/pubmed/33051401
http://dx.doi.org/10.18632/aging.103723

Ejemplares similares