Mitochondrial DNA Affects the Expression of Nuclear Genes Involved in Immune and Stress Responses in a Breast Cancer Model

Tumor cells without mitochondrial (mt) DNA (ρ(0) cells) are auxotrophic for uridine, and their growth is supported by pyruvate. While ATP synthesis in ρ(0) cells relies on glycolysis, they fail to form tumors unless they acquire mitochondria from stromal cells. Mitochondrial acquisition restores res...

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Detalles Bibliográficos
Autores principales: Grasso, Carole, Eccles, David A., Boukalova, Stepana, Fabre, Marie-Sophie, Dawson, Rebecca H., Neuzil, Jiri, Herst, Patries M., Berridge, Michael V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732479/
https://www.ncbi.nlm.nih.gov/pubmed/33329014
http://dx.doi.org/10.3389/fphys.2020.543962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732479/
https://www.ncbi.nlm.nih.gov/pubmed/33329014
http://dx.doi.org/10.3389/fphys.2020.543962

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