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Mitochondrial DNA Affects the Expression of Nuclear Genes Involved in Immune and Stress Responses in a Breast Cancer Model
Tumor cells without mitochondrial (mt) DNA (ρ(0) cells) are auxotrophic for uridine, and their growth is supported by pyruvate. While ATP synthesis in ρ(0) cells relies on glycolysis, they fail to form tumors unless they acquire mitochondria from stromal cells. Mitochondrial acquisition restores res...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732479/ https://www.ncbi.nlm.nih.gov/pubmed/33329014 http://dx.doi.org/10.3389/fphys.2020.543962 |