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Cellular and Mathematical Analyses of LUBAC Involvement in T Cell Receptor-Mediated NF-κB Activation Pathway
The LUBAC ubiquitin ligase complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits, stimulates the canonical nuclear factor-κB (NF-κB) activation pathways through its Met1-linked linear ubiquitination activity. Here we performed cellular and mathematical modeling analyses of the LUBAC involveme...
Autores principales: | Oikawa, Daisuke, Hatanaka, Naoya, Suzuki, Takashi, Tokunaga, Fuminori |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732508/ https://www.ncbi.nlm.nih.gov/pubmed/33329596 http://dx.doi.org/10.3389/fimmu.2020.601926 |
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