Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells

Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and regenerating muscle using single-nucleus RNA-sequencing (snRNAseq) of isolated nuclei from muscle fibers. This revealed distinct n...

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Detalles Bibliográficos
Autores principales: Kim, Minchul, Franke, Vedran, Brandt, Bettina, Lowenstein, Elijah D., Schöwel, Verena, Spuler, Simone, Akalin, Altuna, Birchmeier, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732842/
https://www.ncbi.nlm.nih.gov/pubmed/33311457
http://dx.doi.org/10.1038/s41467-020-20064-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732842/
https://www.ncbi.nlm.nih.gov/pubmed/33311457
http://dx.doi.org/10.1038/s41467-020-20064-9

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