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High-resolution ex vivo NMR spectroscopy of human Z α(1)-antitrypsin
Genetic mutations predispose the serine protease inhibitor α(1)-antitrypsin to misfolding and polymerisation within hepatocytes, causing liver disease and chronic obstructive pulmonary disease. This misfolding occurs via a transiently populated intermediate state, but our structural understanding of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732992/ https://www.ncbi.nlm.nih.gov/pubmed/33311470 http://dx.doi.org/10.1038/s41467-020-20147-7 |