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High-resolution ex vivo NMR spectroscopy of human Z α(1)-antitrypsin

Genetic mutations predispose the serine protease inhibitor α(1)-antitrypsin to misfolding and polymerisation within hepatocytes, causing liver disease and chronic obstructive pulmonary disease. This misfolding occurs via a transiently populated intermediate state, but our structural understanding of...

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Detalles Bibliográficos
Autores principales: Jagger, Alistair M., Waudby, Christopher A., Irving, James A., Christodoulou, John, Lomas, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732992/
https://www.ncbi.nlm.nih.gov/pubmed/33311470
http://dx.doi.org/10.1038/s41467-020-20147-7

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