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A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice
Among laboratory mouse strains many genes are differentially expressed in the same cell population. As consequence, gene targeting in 129-derived embryonic stem cells (ESCs) and backcrossing the modified mice onto the C57BL/6 background can introduce passenger mutations in the close proximity of the...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733020/ https://www.ncbi.nlm.nih.gov/pubmed/33336163 http://dx.doi.org/10.1016/j.isci.2020.101870 |