CRISPR/Cas9-mediated generation and analysis of N terminus polymorphic models of β(2)AR in isogenic hPSC-derived cardiomyocytes

During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β(2)AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association studies, in vitro experiments with primary cells, and...

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Detalles Bibliográficos
Autores principales: Kondrashov, Alexander, Mohd Yusof, Nurul A.N., Hasan, Alveera, Goulding, Joëlle, Kodagoda, Thusharika, Hoang, Duc M., Vo, Nguyen T.N., Melarangi, Tony, Dolatshad, Nazanin, Gorelik, Julia, Hill, Stephen J., Harding, Sian E., Denning, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733025/
https://www.ncbi.nlm.nih.gov/pubmed/33335946
http://dx.doi.org/10.1016/j.omtm.2020.10.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733025/
https://www.ncbi.nlm.nih.gov/pubmed/33335946
http://dx.doi.org/10.1016/j.omtm.2020.10.019

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