Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate of <8%. Unsupervised clustering of 76 PDAC patients based on intron retention (IR) events resulted in two clusters of tumors (IR-1 and IR-2). While gene expression-based clusters are not predictive of pati...

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Detalles Bibliográficos
Autores principales: Tan, Daniel J., Mitra, Mithun, Chiu, Alec M., Coller, Hilary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733475/
https://www.ncbi.nlm.nih.gov/pubmed/33311498
http://dx.doi.org/10.1038/s41525-020-00159-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733475/
https://www.ncbi.nlm.nih.gov/pubmed/33311498
http://dx.doi.org/10.1038/s41525-020-00159-4

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