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Chromatin topology and the timing of enhancer function at the HoxD locus

The HoxD gene cluster is critical for proper limb formation in tetrapods. In the emerging limb buds, different subgroups of Hoxd genes respond first to a proximal regulatory signal, then to a distal signal that organizes digits. These two regulations are exclusive from one another and emanate from t...

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Detalles Bibliográficos
Autores principales: Rodríguez-Carballo, Eddie, Lopez-Delisle, Lucille, Willemin, Andréa, Beccari, Leonardo, Gitto, Sandra, Mascrez, Bénédicte, Duboule, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733857/
https://www.ncbi.nlm.nih.gov/pubmed/33229569
http://dx.doi.org/10.1073/pnas.2015083117