The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides

Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the methylerythritol phosphate (MEP) pathway. Here, we show that mutations in the Plasmodium falciparum glycolytic enzyme, phosphofructokinase (PfPFK9), are associated with...

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Detalles Bibliográficos
Autores principales: Fisher, Gillian M., Cobbold, Simon A., Jezewski, Andrew, Carpenter, Emma F., Arnold, Megan, Cowell, Annie N., Tjhin, Erick T., Saliba, Kevin J., Skinner-Adams, Tina S., Lee, Marcus C. S., Odom John, Audrey, Winzeler, Elizabeth A., McConville, Malcolm J., Poulsen, Sally-Ann, Andrews, Katherine T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733947/
https://www.ncbi.nlm.nih.gov/pubmed/33293381
http://dx.doi.org/10.1128/mBio.02842-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733947/
https://www.ncbi.nlm.nih.gov/pubmed/33293381
http://dx.doi.org/10.1128/mBio.02842-20

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